Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome complement as well

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Differences between males and females are normally attributed to developmental and hormonal differences between the sexes. Here, we demonstrate differences between males and females in gene silencing using a heterochromatin-sensitive reporter gene. Using “sex-reversal” mouse models with varying sex chromosome complements, we found that this differential gene silencing was determined by X chromosome complement, rather than sex. Genome-wide transcription profiling showed that the expression of hundreds of autosomal genes was also sensitive to sex chromosome complement. These genome-wide analyses also uncovered a role for Sry in modulating autosomal gene expression in a sex chromosome complement-specific manner. The identification of this additional layer in the establishment of sexual dimorphisms has implications for understanding sexual dimorphisms in physiology and disease.

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doi:10.1016/j.devcel.2010.08.005
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Dynamic Content (website,portal, blog, newsfeed, etc.)
Language(s): 
English
Date created: 
2010
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